	   SnapGene      TGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCgccaccatgttcagctggctgaagaagggcggggcccggggccagcgacctgaggccatccgcaccgtgacctcatccctcaaggagctgtatcgcacgaaacttcttcccctggaggaacactaccgttttgggtctttccattcaccggcccttgaagatgctgacttcgacggcaaacccatggtgctggtggccggccagtatagcaccggcaaaaccagcttcatccagtaccttctggagcaggaagtccctggctcccgcgtgggtcccgagcccaccaccgactgcttcgtggctgtcatgcatggcgagacagagggcaccgtgcccggaaatgctctcgttgtggacccagagaagcccttccgcaaactcaacccttttggaaacacttttctcaacaggtttatgtgcgcccaactccccaaccaggtcctggagagcatcagcatcatcgacacgcctggcatcctatcaggtgcaaaacagagagtgagccgtggctacgacttcccagctgtcctgcgctggtttgctgaacgcgtggacctcatcatcttgctctttgatgcccacaagctggagatttccgatgaattctcggaggccatcggtgccttgcgtggccacgaggataagatccgcgtggtactcaacaaggcagacatggtggagacacagcagctgatgcgcgtctacggggcgctcatgtgggcgctgggcaaggtggtgggcacgcctgaggtccttcgcgtctacattggctccttctggtcccagccgctccttgtgccggacaaccggcgtcttttcgagctggaggaacaggacctcttccgtgatatccaaggcctaccgcgccatgcggcgctgcgcaagctcaacgacctagtgaaacgggcgcggctggtgcgggtacacgcttacatcatcagctacctgaagaaagagatgcccacggtgttcgggaaggaaaacaagaagaagcagctgatcctgaagctgcctgtcatctttgcgaagatccagctggagcaccacatctcccctggagactttcctgactgccagaagatgcaggagctgttgatggcacatgacttcaccaagttccactcgctaaagccgaagctgctggaggcgctagatgacatgctggcccaagacattgccaagcttatgccgctgcttcggcaggaggagctggagagtgtcgaggctggagtgcagggcggtgcgtttgagggcacccgcatgggccccttcgtggagcggggccctgatgaagcaatagaggatggtgaggagggctcagaagatgatgccgaatgggtggtgaccaaggacaagtccaaatacgatgaaatcttctacaacttagctcctgctgatggcaagctgagtggctctaaggccaaaacctggatggtgggcacaaagctacccaactctgtgctggggagaatctggaagctgagcgatgtcgaccgagacggcatgctggatgatgaggagtttgccttggccagccacctcattgaggctaagctcgaaggccatggtctacccaccaacctaccccgccgcctggtgccgccttctaagcgacgacagaagggctctgctgaaggtggaggcggatcaggaggcggtggatcgCTCGAGatggtgtctaagggcgaagagctgattaaggagaacatgcacatgaagctgtacatggagggcaccgtggacaaccatcacttcaagtgcacatccgagggcgaaggcaagccctacgagggcacccagaccatgagaatcaaggtggtcgagggcggccctctccccttcgccttcgacatcctggctactagcttcctctacggcagcaagaccttcatcaaccacacccagggcatccccgacttcttcaagcagtccttccctgagggcttcacatgggagagagtcaccacatacgaagacgggggcgtgctgaccgctacccaggacaccagcctccaggacggctgcctcatctacaacgtcaagatcagaggggtgaacttcacatccaacggccctgtgatgcagaagaaaacactcggctgggaggccttcaccgagacgctgtaccccgctgacggcggcctggaaggcagaaacgacatggccctgaagctcgtgggcgggagccatctgatcgcaaacgccaagaccacatatagatccaagaaacccgctaagaacctcaagatgcctggcgtctactatgtggactacagactggaaagaatcaaggaggccaacaacgagacctacgtcgagcagcacgaggtggcagtggccagatactgcgacctccctagcaaactggggcacaagcttaattaaCTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  B©   #          1   ,   $   !      .            2   )   6   +   /         #   4   !         $         $            #   2                                                  %         (   ,   #   "      H      (   6   #   ,   "   0   #   &      .      #                        *   5      &   %      -      4                                  '          %                              (   #   !                                                    &   0   &   4          "   %                     '   .                                                                                  +   $   "      %   *                  &   %      "                        &            )   !         #      	               0   2   %         /   -   #      #   (         2                ;   0       '                     %   2      +      '            8   /   $   #   "   .      '      !   /   $   *        # ñ y£ªF„<	>?†Ã��‘–›ª«Ìú¨©Òz=zü‡	ºö  yzœ¸úNQ=	$º
¬µÍyY^rßýZˆ
ß¯N¹†: – ò �	’½‡’—.¶èÕ€Ð{»`Î	1 · `æŸ¤«ÈGSZfXgs…¦!	Û	
G
n
ƒ
¤
õ
@Äâœ×ûªû›Ó/n{>Ë�O³÷Ž, C “�ûOØöw@Ðå*½’¥Âû7:@P£>	r	ë	÷	)
D
%»x­$òþ„
‰°;$ ù}ÕÀRVG	ål>e¶ìLÄÛ#Z¦Ò[:À=ËOèo‡—! f{š	i	ñ	 
°Îz1CId€%v¹ëþíÆšàûºá5 z¹æ¬¥ÆÊP
Ud`¡:_.Ùåsà¢. �D÷>Dhï'`cJ\ž¾Á	À	è	ý	
›
ˆœB“˜Ô/4éÖ�÷£Ñ‘7àö”pa $žåês1Ûð*€š¿ÕIj§ — Lmœ7·ï’pÛ|Ç5z‘øp¼ñ0Ï
 F ó þ
“:r�£	ž
cÆÆ=¼çC þ2 œ açî ½HT­íþYî	ú	
o
¥
AÝRé+Ô0o¾aq‰Ö»ŽžÔíS”³ÝÌ˜®ø�) o ®õR©3ZÉ\[gÎ3hû"	a	H
u
„
Ø
ö
éŸÅ�ÄÌó;œ|²XbŒ6s6 t 40\•‡°€…L§	�	Ü	Å
h¶Øàü�«ç/ªõ‰‘¬Å"d°ÁÔ?ZÌñÌçÎaP´é¬+ ¸ +ì¥¬ºGKèûÜt†	~	�	¨
›¾à÷{¥ãüŠÇÍx&­È|*5GùÀ/ D ü¸÷Ææp¾ü8Je˜¡¤p	Ž	ì	ø	E
l
�
¢
„¼yšàc®çÅËðóÿG‡tŒ�Ó`± PÀíAsÑ+?¦A?	\		
*
’
&(È…=…Ÿ¦ŠíÙ‰< M ”žuCQ	s	*Ùz%d&�éD9WÏsŸ# X yÙx™Cy¸“Ã;€N	
‘�Ýü 5nµÿ*×"rÏdÝ4 ˆ ™œ!~ï8S_bq†¹ò�­H	š	Ø	å	
8
r
8©æý?·÷?èT[r2Á	ñ-£PpÁ! 8çÖ;WÝ¬í6mfíÜ$¡ï§�ÃÛ\—>’Ðéû˜ø ‹ Ý¹A	”
q·ÅÿšÓw‹ˆ í  ú¤Á,
‹BñM[M;\ÌÑ$  ° G$ÂÚ9A¼ËŒ›°³Úø	R	j	m	
£KÏìDaµ´&Œì_# ½ gÓªû¬î¡ªÑ»â Ï |Ó#
±½ãp{„¢Weº@¨®Ç‡áïð$ €	k‰ò	
/õ27J�Ï )wïÿS›¦®üqÆØ=6>F Q]†Ùâ“Ý0^	Ñ	;eÊÚ,H/na’áo‚Á,2 } É ÂS"-¦ËÔ	Q
½
Vò¢º?¥æžŸH’ Ö {rºC*¥†¨±Õÿ
ahÿ;®—`Ât¸£¤‘l# y 8CR³Éç­Ç ÄX	Œ
à
I$‡²8FÔêîä‚Ú†Š©ÝnÛ›2 ‘døE�®ä~ªù(Qad}¿		é	þ	N
œ
^�£”™Õ25ù8ÂÙ!‚ ¤ÆÔx’ô÷É’ EÇwÑŸÂ‰¡Dêî€ùÙ( ^jqb < > »ñKE
€0ÉË×¾Ò×8Tœ•"�  R ?Ï%ið S]7	Á	b
D-CÃøBu(fÌVáÇåÜ1# O ë|öë':ÚJkž] å %mŸæÊ¾ñ@�›À;Y[& + `–½-ÞPúB#¥2�Ÿ˜Ü+Ö1¨’ñ 	 ³ ²Ë#Vótn>
Ðu @ Æ áÈ!KîÈu?MFŠHz}â
¡� " ˜ Û 8“Ñ6áù4ÚLhÑò$1Ð Ÿ Mn ¤c�au	èNØ"{Ð’V¶qyo£Z  û d�Màˆ¸ð-B“qÀÜ3Rf}ÊØ3Aeë`½ï G ÇGU	Ÿ
Ž}¦WcÇ>™ / ô T‰Ü3–´{,z‚™Í[ÉåN‰Ç‹è—O�± …ÿ@|°¤	
UÛvd›Š½Dv=Ö �”;’s�ÐQ'à(hóõ‘!ÿ% Jkè¡ëZ‚ï	û	¦
ÞÒê),W¼¿×pú…�ÒÙîÞnï–ß V ® ±¾„P	Ï	
p
°µpíþrŠ�Õ•Ño×Í™ù� � Ä bïaŽ¨÷>z®_BSB1ì¼=–KT´¯X( T ¤ '—<IUäîóÿ'=W_ÍÕ:DbdHøBƒŸÀÎu#�sÄ, ¯ S	z3e¿4UÙ

¦ê“ žÁ?ðô8<ÂmÏ<}E)³¶Ì�„�7Î# Z p à4[úk\õ’üv
Ü
¼¦þF_·B$/Y}Ìù&uçft~"  „ ö¹EK]ob	÷
lqÅ KOSÅ÷7fJH_mot�?EÄ   ªÂãUÊh•Ïi#	2
I
d
…
–ÆÍi�Xc:3H J ¦ 5Y’–Û'A±�™¡Í6Wºðht�Åõø+=Mõ 	9	K	f	â	 
;
Fi·Í×òÉ÷Ÿ«­Æ#?e±ÂÍèÍl½ÏP$LQr*gÉ e 9]�1é*	‘	Æ
M=JßŠ’hÕÞò±,ãS†( 8 u ‘ © )1od©$".Í
Ìán�Åö|Ë“±	 *Í,·O©æUµ­b6  1 {ˆÛ»K†™ù¨ï	–	Ý	
 Ùýež¬è0°D–@[:èD¡±Ââb…ÄÐE%MÄâêœ·ö¤Þ#  H{–¢ï(¶¹	Ã	Œ�ÈÎy¸»wœJ—®É7·äHãK{, ' ¹ rÆ…­»Léüæµ		ƒ	ž	|¦ESƒý'FVžh}+6¬¹0d€TÆ%" 0ñXòlÝwy	¼	Æ	·
]l¿áNú/‹Ñ×�OYºùwú�20 ,<J¦ÏíýÕ¦›Ñò)ÅDu‡z
©
œøä"Yamy‚Ž˜£×úÜj•KgjÁª# • xMžÇWf¥Ú	
F
m
‚
£
ô
…á©µçxÔÑ]<Þ²…�Í& ×ø|¿ÅUÁ69™¢Éq	ö	(
Tcwd ¯ñBH
$uä9¡Å™ún E ý9g_qç	š
›A~oÆ�)<Ô. n s › í¹çÛýK	�	œ	í	ù	t
½èzÃèæò.:ÆÌô ˆY`�ì)4F`²Üa‹Ër ÅìBrt>B—
')ƒßÄ<†4´‹ŽÎèCV# Š ›î:^a¸¬@	×	+
“
¨«ì5Apðö>ç ‘¢ŠÐ÷ ¼ #Ò@ˆ»¯

~.J©`§«†¥î ï^= QÁ!,§]	‹
ß
:É#g†¹>¤éžÚ Q ºvDR	a
¢Âø7ít'óÈ]Æ!�Û"  * N ä l•±Ê"UOm{ùAê¤0:X\t ! Ú ú Ÿßt	Ð’et2ê3EK‰_gnÐ  2„€Ï+Ú&ß'ZgVŠ�<€ j`°�O	Î	&AV^ÌVìýëGo�÷ØÐmnîWÞ* Y TyDJ2d”‘Û
	’•»¥Àï7J^6AG^#.sµË€ƒø9ÍDeÃ5 d Xnz‘ÚcŽÌ5¹ø0gsŽÄô!<îÿ)	J	•	
:
Ì
ÿËö�žÞ>+°¶Ì+káÃKLR¶õ & šñz•î‚	y
\ùI i¸/& m r �Ö^ÚTÈ	›	Ù	æ	
'
s
™
çv@¨w\_Åë(3E˜ÝùÊq„Œ% ‰ š"9=]`‡º®
Þ
9}ª"4@Io¸ï;_è3ª�B¡¤] ¹ÉƒÞÎ`
Þø&@és£‰ò/[Ú!- % c WmðË÷críó �þ(	I	”	Í	9
x
þÊ%œIUëŽ@]Â
J.QíÂ <ì'	nîÝ %H¢Ä?\ê'2D©A—ø.ìÙƒ 4 \ ¯Â]mX	­^ÚÛÜ–—˜ª«¨&1BC{|?@“”•–Ñö÷éêëØêühiv€�‚ùú ] 'è°Ãâ9×ÔÞ_g£™¬©‚;OXÜ}$w™û  ¡gè6^ün	Y	®î7¾ìÝGðƒ]˜[_Ò=þëýjÿ (ZŒßé]™ÄãØº`šÆ ¹ªƒ2Œ#tRÎxšî á Wu>”Õ[½4›<DYóûkŒ´¾‰¡¸ü ^ € ë :ÞÐh­¸¼V²PÝî9DC  Œ ç ±ßB	•
r¤¨ÔÀx~%)Y @oµ¥ý
w˜ï‚²€ÍwÃì j ÌûoÂZ-
¯NQ§\¡ñøÂ\k  ¢Ïhéý-é1	Œ¿ÔÞHsˆN„/ƒþÓ>¤(Òþ9 !7_5©	¯	T
ê
8CíòXa™^<™]•`ÿ{(' 
)�êB^šä<»%Ìqœ»ù	¡	
B
"õÞí¨b®‡¡«3Äª.4N  † [àÛÓ�±Ûk	n	6
�
a›EU•'„Áí$uë7ÏÖÛ ± bÅ‹#OS	\Ç�™Øà$›ï%  ÄûH%·ÙÃ:éB½&´d	0
¤LÇÐüDMÀ¶µºh�SR`”y  â ÿ jvhKR•,¾	5eéEÊ^‡l�Ë X\u0=Z
§¢üA¼Šý ¾ ÂÔ*%œü35¹ç À ?Ö4«Ç¡ûô­ï«Òµ¿¢¨ã � Ì Ó NƒÖ�Ú‚‹	is²�Xfkþ&Þ:šEƒå¾Ó Ð Þ ì ÷ ø/<;$
Ñ"ä¹W6qÈˆðA» _ ˜}Ô¾q|…£®³¼+©QaâzñÆéó ß…Šh½œâ�à»A¯oï²D„ 65àPì
n¥ K©ôù¿4LVÕy‡©�7( è ¶¿Z²GMd³*-ó	X
–
ç
€sö8«!9žá¡J‰–ÁÞvó&ZõÇ'âÊ#  - � '¶~œàC	q^	Q3‚Œ*x ‘-œ¯ý*ir¼	>G?! �¾Ïi_
ÖlŠh
À
ù
”0	}'§Ððäü|T§	ƒ.8ÙWG µ ï "œãw¶õ1DH_	Ö
<f™ÛÊ-o/ö¸­·•3 AAå„ÿþØÒ	
6ðƒ˜*0b¤ýpZ¢Î¨Ä R^‡Ú+”xŒ†ô+IØxí- Â pÍÞV¦j"Ë;³kÉ“â�ƒ"‹Âàš Ãp0ÃÕ	e£@¢ ŸÃæI‰l  h k ~ ÍÉ§[Ìç%	R
u€È»O¨]Ÿ¦9MVìöy]  Ê ´%X#€(šÑ	.
4
@
f
¾
 2’ó(òçù4ÔÉå üT. î
W°MRô “ £&-¦²i­À NI˜QaOÃjHµ¯¼<Lm: × HþÉ
Yb¯¤„ÿ
¥ |ª»iê+‡©Öê[
 �Oß¥?)ÓN  sÐDþ.å2	²ÕH<Tt‰u…0¹æÔ’*wÿ-¤ª z 9vÄW¢ÌªáY	K
JÅGëÛ‡´£=êodÔæœÁ ?¬ˆ`Ÿ6—ÛÅ¬	U
�
ë
/Y%óbåè‹¯aO¹ |T 	´Êp®È4	†	°	á
Dˆ³Ïï‘Øšª_ñ7e( D‹"S8èk-	¨	´	‡
ð
PÒ9î9ÕYƒõšÞ^–Ü)5& Ž_›åù‘RYer¼ 	;	#¹ÂŽ•š´ËÖùúšmÏyÊœN_0 B ’eõvå
?«Ï)¼‘¤ú?O~	F	h	ê	ÿ	C
O
ä_k=#9KÃÚ"ýcƒ-¥¸ê	¿Êç& Cr=C›&bŽ�À	¢	¿	
�
36î‘¢4yÅ¾õHiæB“¦/oO4 *3­ëôQ¨/[”F†¯¼[ú„Íú	}	Ä
öQž¤ß©!%c¯ˆ¬ÇÕðºR“±ø¿«5  L ·xod 	M	o	�	‘
byæœÜïFm%)!Žì8_rˆcÜ ‡ ˜ £Ü7pŽÜä	7
ŠüZþSÂÚvð,ŸÀì"  Î FÁ8ÒjÊ‹²÷l	"
¢ôâëo¡6V´³Î(úîR­Ð×<% x È Õ 7P\…Øáq’ÜÈ)°ÔÃHÙ7E­–�`…·nÀG�k+ ; = ã$PŸ6	 ]1ÁÈÊØ AÅÓwÖØSUäi ² ¼òÝ=
Ï"Žž&9Ù�‘%ð ? c£ŒLÇA¿Q!Ïà×xG|á#œ Æ³‘zFT	
Pu�ÌÈäòMˆ~šbôu–NÕ S £ I&–ö;êòƒ^¯Ñ9»<A•¿ÑÍt"r• ƒ ¸j¾T1
c
¥kýENÁh¶Ä(lnW|Ë%æ>2'  0 7 � ¨ (&@¨Ú º÷-ô8	e	á	EÈÄ¯Cg•’ )Oâ)TÈ…a£Ý.  ¥ÅüÐÄñ¡Cv´'µx	Â	kM!.DR€Ö·ùv›ÛiŽ–�JgâŒJS©z$ ” š wìL}´æÓ_(;Û –-Þ
³ŸUö   P Ù ã ù k1Á÷6Yfìsˆ^mŽ  i_SíË
º¿]êF¯ËÊKlôÌ $ b l	“	Ì	
&
?$vœÜZ\‹ & çfëë]¢•>[A¨#-<ý×þ à æ Y=ÏZ3»±1¿"8sòXCjB½ nËÓ¦±r‡.‚Áý£' 	aÃú"%[ÝûC¿”À×6©3“M ¿ JQ+t$/ ¦24 Ò Ý —Õ.;‰gŽ»áŒjý%™y@º½Òèò , ¾4ßcÕ]&¦�à3U�•ãÝû,{†¨òhô-&É ´ Á î !›Ì*ô@ƒC×~
Õ
5‹:ÉÈ.üõŠ·§¬¶ 
 g ³$W'æ?
tdL8åˆÓä ,È
X¬KvM£© >u oà3,	§	³	OÑ×ô¢®éð6N¸ÓÀ A ¬P§q	ƒ|	³"�ü~lïÉ¹›GåA¥æ w Ç Í Ô O„×p‘ÛÀÉcŒ	6ánYÍ_�ïQ¬ž¿ë : ¢âžt@!ãL v}ßwF{ãÔ  ‚ ¢ Ÿ¹õ‚w	 jQg8”•ÿ';@”N{‹Iq~„¢¨ “ ™ ø 0ì³ÀåÒXÉóõ # a ß <ek%
ÎÒê#2”¥°º7rÛ"WBiÖ Ñ Ü ù3!$sº¾$.”âúz§ñó,%2¼ÈÑ í  š=+&9È-7è5‰M·ÒJL ¡ Oo¡¦ž¿�bv	m~ûâ|“vz«äp¤ê ` ™d é²¿Ç1r¤¯¹½,#!ò+ÕKÇô+   N¥³l}´µ¶·¸øùú
,àá³ÙbcdeWXrstu²ã dJ²³$ ~~½Õ´«Ujp}’†-O´ªÚRfÑQY·ü³{eP[´" « -«wµN0z´
º
k‰‡.PŽáSB~«ÏË4B:|aûó  ü ŽfØ]
ä
�Âñ¼Sgf €¯³AQµ% ìsà‹ãÉ	†‹ãq~.i¾�rÝµR\gj½pýì´Ef…ð\* e¾ïö‰ÖÍ¬áÏ
2Vty“¹C”ãÁ4"°ÛÒðR¥«Z¸Ù¾® }ãíO1´¦aˆ/�ª
ÐXzÄÌ5;üô8 6.Q¶HV	˜	
 
»
�×ýÒFâúÀ¬§€!0 È¬ß{L{~&ÖdÈÊ?ˆ}š�ž¡/ H ¬ 7áxç
µ
ol�ŠQõBT5CMW¯»Cªb  �He.ªô	�÷Î\Ê":âßŒ0gÆ[lö´BË& é UŠ·Ý[—³Ô û^
—
è
{GtšVT9æ]Šè‡Ÿô'Èy²¶% õ ý À4ÍgµN±´M+|‰	å
oƒŠ¬Ÿ½‡—ÂÈé�°,P‚àã¦Ù uFÙY
-�ÃòO�¢KThê2F³äw Öä˜(R"   . Ž tŒ4	D	ß	wŒä¿ÔÚ4²+¶kwœ '¾Es½g†] ( A}ä
	¥	Ê	
Ó
rVÜ	‡Ûÿ eS¾q­µ+w>  í·½±Ëár/>jÞ]h’£‹íO°þH¦ñ
?H¬  †Ýá�­
_
Ržsƒ�yÒþ.�jF×@ Ò‚¿÷×Îi
ºv‹• uÂôÑÜå¦dÚö}U/¹X  €€ˆ¿j×‹âÑ`•1(Dä(¨±ô€ñSý[G’„ì59  <`“tˆ›m­ñÁ
Ð
3RWgz5…˜#ñÓ¬Ô¨
"ø ¯& 3 fÐð‚Š•0Š‘Ÿ¯
ú
¶'J
u”®áê)2i~<¹Æ ”¿ÚBH ¶ ð x·¢©EPƒ=	-§.XyqÞûY†¹®M¸õ9 ~Ôä¤ð	ë0ØÑì<
–à4 #�äKléöîI[ü	ÓbÚö0�ÅÚï÷6™ßo»ðý) 2JY¬ì2`	§
×
gšµÜß*ŽË‰w�«Ä½ÀÓpËæ{ÍÓWè—­! W x˜¿ ·I[	
k
€
¡
Ç„�™ØÊžûÿsc¥þÖqÒØÎž 7æ…ñ¸™	
q
7¶qî1L™€–[Ïú ¯ ÙÙQ	¼ƒ‹?­p©Å"E# | BB²/¤R…ÿW	Ð	Ó	¼
þ
ñ±þÓí+GãmÁ‰‘¨��Üm£š‘1 cðÆ�­Î}©øÐ|M
C,C½ø'eË›‘0	 _,Éõ½—?Z ž Å bà`ç‡ ,M2Jí×>ÉLUµ@dÙ~y¢	îY SˆÛ•?{¯yT�˜|¥‰˜Ÿ°. U ­ Ã �§=yã(<´Ccù‚„JŒÖÃ  ßÁâùônp>RlÎ;öeDIŽt}0 I ¥ 8˜JV˜ï#è *
LÌÖ<ñIdm{Ê°Ý9çCN ¨°¼Á„Ïå#Dq$fÃá›2 /;IqÎðÔ„(Wkå¸	»	Å	¶
X`‚‹lx��—¢ÐºÖEU6NX”¶¹ãføv«1cÅ% {8fÄÀ5Võ	ó
SbŸÂåñ-9AnÐ	~#;Xã8 ±ÄŠmÌ » 
Äëq ·«Ö	Š
‚§ëf¨õ=Ãæ£�Íç…�îÏ  ) ° !TNl¡Ï‘U12ÇJ\Å;f / �¯bI�14”/f��	Ú
[”ø¤õ@Uî6]Ë=HFö*jà-h´·‚m÷µ8CV- l q ¸È‚VÕÊ]Ùö\ÝÇÍý_
w
˜
Ý
|!3HuÉ§›:^çê^�ˆI~ É~# [ ®Áá5\ûlÓ	&	½ÙF©ÿG:NW‚é%0zZ^õègu   ê Vt‹Þ\˜“¼U§¸C‹í(QÍú³·# i ?´Î,4¨üè0	®	S
é
v—~�PW` ˜÷”'vÂz8( … AŠ;¶º$NèÒ
pc	 	/
5
A
�
!ôÆL§T­g† ˜ÃêÕß-QÚ  þ iÁ3)dÆèÉú	]†@Ê§æ Ë ö M‚÷�Ù�Š	r„!›*ß`n5p‚±ƒäÅ2 µ&5Y½ÎhFLO^²µë),}›W
g
¿
æ
ø
p“mÿP|‹ªóø8¾K Iˆu‚»7ŽVáF väUþi!G—…ó*j)£!Y¡×ß™” È/™Ð$	3
e
í
1‘'ÇžLUëóõ3ÿxÈ  ©%GýäZ
±GMNSPiG´å®»	);,  Š«‡ÃVž¡Ë–Új…	«	J
†
ï
.XÄÎ�ç³cdå4S'; 2ó.Z“ôBu…>ZšÎX�»�£ù>N	:	E	g	¾	Ã
¸ãPjÁ<�ÊøJ™$b,·ÎxéQ¾M°½h¾n^0  K 6—¶(¢7n6io¯Šö	L	ã	!
GØûóxå ¬Û5³ýR²l¶m+¿F�‡;*  Ü²�yÆ5	<
ŸÎOÀÇñ@‡PÄ�ÎÕaÖó%RtMh'  / 6 � § ¤'§•ñu³ö,óà	j®Õ®fšÃÚ‘œkIm¾Ðás!(Ê$= Ø ^Ê
¹Ý
 \r®²T ê	’	Ë	
>Y¡q†°!-ü, Ô:IbZˆÜ\f�à‹“ißT¿¥…gx?L f )ÿ‚B~ß2å+	¦	²	}
Ç
Ô
NsWcŠKÖóä ¶¦‡ 9 v «p¸ô�{	5Pà? }7“Ì”
^¸ŒîP@§ ’ *2j%#ëÍ-“çy¦V¶I% }¼¾²€ªTio|‘±Æ0k÷	ß²+Pûª±*cÔIO±2 ª ëî,erªõˆvŠÌ×/yâÈ	\
³
¹
Î
ã
ŽÁ1âsx!Q[i¼Î¤ª9ÿ®úò@­ |Þâæ—	
³Öü€Ñ`E	Az%®ºÃÉ�.+  tEÌÓÿ°Lú©ˆ	nFUSŽ\†é1E²ãç†/žÅÕkã+xß¥Ø   Ü¼Ê		3	Þ	¬
Ò
ÚþŸ=ÓÙ±v¬¢Ñ&NG¥ «' 2 ‡Ñ‰/‡šžð®
_µ&If­é1uŠŸt„—;ócÅÓÿF“ë4¸÷A ¨IXÓ£«�vÃÙõxÒÊÝåë~˜Vç	Lº¬ { w—£Øð·Z	j
ý
Æ»‚Éì�Kl˜>ˆœÛl�D ÅÍ|ÏL
æ+—¼÷¤>c—Y8  .:HïÓƒÀŒø—â)m·	º	Ä	KÕ;ðHckw€Œ–¡Ïz¹¯Ü8µ¸æM§Ieä÷peÕ0Â|/ ( º ÿ®Makê7Œ“Œ¶€	‰
ò
RZa§ôTäí,5�åGWõTi,7°1Äí:eU$ >sÇ�­ÀU+3ØÜÆÒ	/	­	– 2}ØEéŒ—�~H“PÁ}7# Lh�@ŽØ‰¼:êçŸ	V
Ž
þc{š¦)©Þ…Ÿ\…º6�ÞU" ¨‰$†� ÇýF˜ã„	ª	ì
0&FL„)(æ²òþ­ºbÞÇ+&. 5 1òµó„=Y”m5nx¢®‰ò	½	Â
žâúO;ðü†™Ù�›Ô`l½ÕàòŽ#) ÓaÞ±	|
‰¸X[[Œp… ûfK' 
qôóu‰œxz	Ç	²
¸
â
À04Shw{°6’PZ»úx8©ù° ËÒ¯É‡	«
Ñ
^mE´û%ÐÒØ$ò«­È3! -Gî§‹–Òl¶	ü
Ô:åï*b–jØkö=L›bk—–«C/ =Kg§þ�×#T9œé*2‹Æ’E.	©	ˆ
ñ
QK×ãì+4z�™¥Ý„–ÃÝÀÝ*6$ 4 ÒÑòƒó¡wˆ{
ª
±
�ù·$:Zv¯Zo„ûk¼ÇßJ* EFÐÑŒÖñ1 vµ	°
û
Ó#()•Öâë*3nƒ¤hijº»_`a•ÂÛÜI  2"  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       	                                                                                                                                   
                                                                             	      (                                               	                                                                	         ,                                            	                                       "                                       
                                	                  	                  
               	      6   $         	                                 	            	                                    
         	               8   %      5   (      $   +      (   ¬   _               /      u                                                                                                                                                            3                                                                                                                                                                                                                                                       	                                                 
                           	  (                 	                        	   ,                	             "             
            	      	      
     	  6 $   	           	    	            
   	     8 %  5 (  $ +  ( ¬ _     /  u   ~¯  €  €;  €�  †  ‹³  “Aê‚7Ç	77	7—ó17Çœvò	‡	·	{
ì
ÔZ¡¼Üõ~,>äû‘Uô<‹$) 81À¨·78Hï·é7š)n,¦íá(7‡¡ËnDD€—$‰3þF‡	� ,¦ÆíJbL[é3™Ýðïø"+4Æ	2
áÉá JeƒþFyÈÎÆ1¼Â7[Š•B–ÙK„:\ý79Ú�‘Ûy	
z�Ÿ‘�‘�y�2Aj/
†Ž-”„½	ä,7ÁÌ%797–:3˜	/	7:7:Gkò	7 )6{OBcèÎÕ.µmK	‘	‘ ¡
2ÁØ6£’9qÅs„…áó=¢_2}/4’†£ü=ñ
<`Ü<`’9qÅs.Û½ Q†Ù“,@|U	¤	UŸ¦/ò9rØšmst©sÉïhÀ	H
„
BÌÔ÷b—c8æ€n×ÝwìFJú}	¤w%¬Ç{] Ý¬O—6oã	ûR+@Q†Ù“­RÔ’á®,jÂ ¦× y“b
B VÜ1Qb
V1Q§–
Ö¤s…âÞ ;¹6qA~]¤ÈÏfgs…!	G
b
ƒ
Äâ›øV1Qú}	¤%y¤™s…¦Û	â×ûª>þ—£%É.Ô8·b	ÅKf¥íáô6À˜þ�ÃIc%ä‡HTíþV^Ôž=©s£¤ª‡’“Éæï…�hst„…À	H
„
âB«·Ìç/Ô÷:abÀé¼
ôu>Î»�£ù>N_óëŒÓF\†žP…Ù*ó@§¨ò:ƒ|ØF¡Æz	Ÿ	L
j
ñ
ò
Q:ã+¦Éx…¼môê}¹·Ì‚HWªŒÉäæb8¡p	ðw‹’ì4W9	·É÷ÍLSW	wÅmš\	È@:Ÿ	¦…¬ y¤™ÈÏf“gs…¦!	Û	G
b
ƒ
Äâ×ûª›øB >VÜ1Q=
éÙŸ@:ØÆz	Ÿ	¦…Ê¢«
2V ,íY]’­Hhõüb		v
BÁÅSaŒð8Ki#þ@Fbf�“ÉäKhÕ+P}@:|FŸ	L
¦…	b	.
ÅKf*ˆ.1€vþš¥û=® P	Š5mÿóK %iG;§dé!Õî	éÖÒ‚v‹• dö/yÓ—ôu>Î»6o�£ù>Nã	ûR+_óë@1î6´‚öóà	(Ý·MÁÆ U	¦/m ÊÆ Ÿñäª@|U	¤	N
b
‰U^ð'8Ÿ¦V;1/Q¬ t•Om­D	ô	
{GÜä9æ"+~¶â<]¢X‹íOŸéìÙ8B Â ¦•Ú’@ !HŒÉä��4f�)Õðõ=jpeÈœ³
Ö��4f�õ=jU	¦/jÓ
FÖ\†Œž¸y X	ê†›†
ï
4aÄüŽ¼Ï_ ±"U=
t[Ä
6‘ð4/Üñ	 
1I€vþšû5€	k‰/ÏïS¦ØF1òó„7=Y¢	½	Â
ò
RaâO;ä,W7°½…ÖPÀ+¦\	È…=Ù¦ 3ðetõ+Ù
i“?­<eÂE)l½Ïr³¶�É7· +ì¤¥«“æ:¬r�Æst…†¨
›÷âãûÙÀ þ§¨ÒØxÝ—L«DžÁˆépaÙ-Ã�äR“æ:¬r�ÆÙ þ3eÙ
“?<E)³¶�7¦ ðtõ+i­eÂl½ÏrÉ¼êV
þ{©Ÿº6UË›ø	
ìa1_	Ö
f™ÛÊo{» ¦ 3–ëðetõ(+¹	Ã	¦
Ù
iÞ“)?Îy­¸<e¼¿Â®7E·)l½ÏÒHãr³¶�É7–{1ò§¨ó„Ò7=Y¢	½	Â
ò
RaâO;ä,ØxWÝ7°½—L«EK]÷
lO÷7JHt�E G$Â9A¼³£KÏµ´Œ_-iÀI˜a¯¼m( ÿMk�T1Ä:eš	i	ÎC%ë½Îh^g
¿
ø
“|‚7V ©/ÅkK ¶n	L	xåÛl‡y¸^rß�”�à(h"œãõÄÌHK
 NOÃ/£ö=IL K ’ ¶n©ë		L	’	Ë	
>xåÛl/Åk‡¡Ç\Å %MPiG´®»;ÝÊ’á‚Á>z®S¯-Gî‹l¶	Ô:ïbjL¡‚,Wpú…‹ rCA	”
*qÙ%;º@t®Ów¸�‘/Ð	�+Gm|‘¥�˜Ÿ.1 }×ãªi
�wäºÚ/4²
kÐŒÚ;¾E†qôu‰xÇ	²
¸
â
À0wPZ»8ùœSš	Ø	å	r
æ?[pmÊÇÂ,8DN€6�À4L—Ñj&ˆ ™!8_†¹­
8©·2£íËárh£þñ?¬*Ù%�rC;t¸‘ÇÂ,DN€—j‹ A	”
qº@®Ów –ë(¹	Ã	¦
Þ)Îy¸¼¿®7·ÒHã–{%¡MPiG´®»Ç\Å ;† Û�Û6
Áuü fä
¼€¯•3ÎXU ­ Ã �§=yã(<´Ccù‚„JŒÖÃ .:HïÓƒÀŒø—â)m·	º	Ä	KÕ;ðHckw€Œ–¡Ïz¹¯Ü8µ¸æM§Ieä÷peÕ0Â|Jkè¡ëZ‚ï	û	¦
ÞÒê),W¼¿×pú…�ÒÙîÞnï–ß	 ³ ²Ë#Vótn>
Ðud Xnz‘ÚcŽÌ5¹ø0gsŽÄô!<îÿ)	J	•	
:
Ì
ÿËö�žÞ>+°¶Ì+káÃKLR¶õT ¤ '—<IUäîóÿ'=W_ÍÕ:DbdHøBƒŸÀÎu#�sÄØ ^Ê
¹Ý
 \r®²T€	k‰ò	
/õ27J�Ï )wïÿS›¦®üqÆØ=6>F¸ +ì¥¬ºGKèûÜt†	~	�	¨
›¾à÷{¥ãüŠÇÍx&­È|*5GùÀ¨IXÓ£«�vÃÙõxÒÊÝåë~˜Vç	Lº¬… AŠ;¶º$NèÒ
pc	 	/
5
A
�
!ôÆL§T­g† ˜ÃêÕß-QÚ& d t ¸ +4ì0X\nz‘•¥¬ºÚGKc‡š°ñz€ŽÌèû5…•¹Üø0gsŽÄîô!<Lt†§îÿ		)	J	~	‚	�	•	�	Ü	
:
y
¨
Å
Ì
\h›¶¾à÷ÿ{¥ËãùØàöü��«üŠžç/ªÇÍÞõx‰‘¬Å"&>d°ÁÔ?IZ­ÈÌñÌç+°¶Ì +k|Îá*5GaÃKPi¸ù/L´ÀéR¬¶õ … ¿ þ 	aiÁÃúAJŠ;Q¶º"$NèÒ
%pc	 	/
5
A
�
!3ô)+[ÆÝtûCLd§¿$T”­Æg† èÀ/˜ ÃÉú	]¦×ê246†©Õß-3@Q“Ê§ÚæMR^‡Ú+”xŒ†ô+IØxí-ƒ ¸j¾T1
c
¥kýENÁh¶Ä(lnW|Ë%æ>2R^ € ë :ÞÐh­¸¼V²PÝî9DCËÒ¯É‡	«
Ñ
^mE´û%ÐÒØ$ò«­È3D ü¸÷Ææp¾ü8Je˜¡¤p	Ž	ì	ø	E
l
�
¢
„¼yšàc®çÅËðóÿG‡tŒ�Ó`±# a ß <ek%
ÎÒê#2”¥°º7rÛ"WBiÖE d R^‡Ú	+”ýXnz‘´ÊÚcp9gŽ®Ì5_q¹Èø04gsŽÄô!<îÿ	)	J	†	•	°	ç	
:
š
Ì
á
xÿDˆŒ›³ËA~ö†�Ïô+žÞoï>I‘ØšÆ+ª°¶Ì+_ká�Ãñ)<KÔ7LØeRx¶õí(-6.Q¶HV	˜	
 
»
�×ýÒFâúÀ¬§€!0  '     ¯  S        S7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÏ}ŠÓƒ…ðL~öó|‡í¿µâlÜW®¿àAwŸ*€º½­ðþ…áë5`Ž<=&MðÕ}:ÛÒ~¸AKø;ó /Äý÷ÇŽ²-�ƒÑ|�ÁXîÊ DSúóWµþ¨Þ«µÐ©ˆÏ×¿×Ð¾M´Ûlw>¾mÕtD„òqëôâøÎ
Ž2í¶èî¡�ÝNjñ…®Ál#èÈ=ÄFó ž×PÑØ GtÓ†3.píˆà5 7>¾³.vƒ¾¸/ÓÎú#Á×Ã.«�Ð~ëÈfõŸ3ØÃ8ÍN×’ÀÌ8#w:vÛN~TF?pŠÀPUÔQM8o…8ø¶ê1FôàM÷nÿ�¯‡�EÐN(`Ý‡­õ+ÞÎTñN8ÎFŽÔv�S¦<ã¬4NH±�Ê„üØúÈ þSY`„;EcÅ€‚Pu/Vq…n¹×¤ïŽ58H;”=Wà`€ÝSŸ×¸Ž E¸á1‹Ãc�†J� ô÷í¡S±CØ.}~Ï>óë”Çã…Á´ÂæM@ÄŠß ‚?o‚ÄàpÇ%p÷R´È¼11�~pÔáþ­¸ß|58ü�àýþÈ}þÜ24Ž´óŸñ÷aM7ºÔ¼ö?9ËÐLßnºÔp×�Gó<B¬@Ç‚Í±8P6Ç­Avøu8uë]=×.fØ<u4QpÛP…ëQ¼÷]±24ìñ÷ŸMöÃ?Èã�Ç_yøMý/?„ÕõÄS1·`¾8²<ð{°ØN'RNÄ¹?*Wó†Óìx�®J==¸¢£þÿÈúúàP�{÷‹êùeXAZ6Í¢á$"Úæ¸  AÓP€QÖMŽ cæ¸CEôàä ›ýÌþ$Ã6”Ì0")ÌÓ!ó�èôÏäÏÎú³«¯ëêì÷+<:¿ËS¹[ ;ú�+Æ¤Ž§ûõUèi+rHlþ*¬þ¡Ê½ÊêY {¢½^×{_æì.kª™@j�°ù ¥U„á©uV¥ÌZZâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ¸û„æ½’Cª Cä:£UNüè™½ªÁ¸mDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~±Á°»ñ¿æ  …  Õ  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  |<?xml version="1.0"?><Features nextValidID="15"><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7525" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6734-7525" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7526-7594" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4438-5232" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5978-6563" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="11" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3600-4028" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="10" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4042-4371" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3330-3554" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4222-4357" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5406-5527" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7595-7699" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="Ehd2-m" directionality="1" translationMW="61175.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3286" maxFusedRunOn="3286"><Segment range="908-2536" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3286" maxFusedRunOn="3286"><Segment range="2567-2569" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2570-2572" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2573-3283" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="2Ã—Linker" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3286" maxFusedRunOn="3286"><Segment range="2537-2566" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>8b47f1d3-8b04-45fc-9608-7f0299402e31</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:8:52">2025.5.30</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Ë<StrandColors><TopStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="2536..2565" colors="blue"/><ColorRange range="3283..3285" colors="blue"/><ColorRange range="3286..7762" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="2536..2565" colors="blue"/><ColorRange range="3283..3285" colors="blue"/><ColorRange range="3286..7762" colors="black"/></BottomStrand></StrandColors>  %c     ¨  5        57»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÏ}ŠÓƒ…ðL~öó|‡í¿µâlÜW®¿àAwŸ*€º½­ðþ…áë5`Ž<=&MðÕ}:ÛÒ~¸AKø;ó /Äý÷ÇŽ²-�ƒÑ|�ÁXîÊ DSúóWµþ¨Þ«µÐ©ˆÏ×¿×Ð¾M´Ûlw>¾mÕtD„òqëôâøÎ
Ž2í¶èî¡�ÝNjñ…®Ál#èÈ=ÄFó ž×PÑØ GtÓ†3.píˆà5 7>¾³.vƒ¾¸/ÓÎú#Á×Ã.«�Ð~ëÈfõŸ3ØÃ8ÍN×’ÀÌ8#w:vÛN~TF?pŠÀPUÔQM8o…8ø¶ê1FôàM÷nÿ�¯‡�EÐN(`Ý‡­õ+ÞÎTñN8ÎFŽÔv�S¦<ã¬4NH±�Ê„üØúÈ þSY`„;EcÅ€‚Pu/Vq…n¹×¤ïŽ58H;”=Wà`€ÝSŸ×¸Ž E¸á1‹Ãc�†J� ô÷í¡S±CØ.}~Ï>óë”Çã…`„ÔA8­ð#öø,NrWu+L‹Ã1÷çNáJÛ�÷ÃS�Èþßì‡ßáýÃ#HëO9ÿvÓqë­KÏcñCœ½Íöë­AÇyÔ3Ä!JÄwø!|Û…lzÔp×o€7S�'^µÓÝræmƒÇSEµ^µÏuÛpÓ#NÏyôÑwÿl1ÃüŽ8üu÷Ÿ„ßÒóøMQÿ\E3vã�+!óÏ·»�Äâu$ìK‘ò¥8m>Çˆúä£ÓÛŠ*?ïü�¯¡þ÷¿x¾¯–U„£lÚ.B-®k€ €45 hdÐØà0€î`ë„0T_N î@	¿ÜÏâL3iLÃ ‚œÍ29Þ�LþLüï«:ºþ¾®Ïr³Ã«üµ;•°¿©¼jHêpß±ÿU^†�!‚·$€öÏá‘ÂªÏê KÜ®¥’º+Õà]wµþnÂæº¡©”¨ñ«š
UXN—Uj\Å¥® Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û�¸NkÑI!:ª>Cª5TïÀN‰›Ú¬†ÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬VSý~=·«÷Ï>¹…B€ë²«ÀsÃ�†ûÓ0íŽ®³÷ýz*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹‰Ÿ,~ääNƒ%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy]& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË¿þ`  …  ·  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  2<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="13" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3256" maxFusedRunOn="3256"><Segment range="2537-2539" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2540-2542" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2543-3253" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Ehd2-m" directionality="1" translationMW="61175.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3256" maxFusedRunOn="3256"><Segment range="908-2536" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7565-7669" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5376-5497" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4192-4327" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3300-3524" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4012-4341" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3570-3998" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5948-6533" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4408-5202" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7495" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6704-7495" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7496-7564" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>4fe95725-b311-488d-82a7-5e84fea11bf2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:53:42">2025.5.29</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  o<StrandColors><TopStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="3253..3255" colors="blue"/><ColorRange range="3256..7732" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="3253..3255" colors="blue"/><ColorRange range="3256..7732" colors="black"/></BottomStrand></StrandColors>  %     §  2        27»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÏ}ŠÓƒ…ðL~öó|‡í¿µâlÜW®¿àAwŸ*€º½­ðþ…áë5`Ž<=&MðÕ}:ÛÒ~¸AKø;ó /Äý÷ÇŽ²-�ƒÑ|�ÁXîÊ DSúóWµþ¨Þ«µÐ©ˆÏ×¿×Ð¾M´Ûlw>¾mÕtD„òqëôâøÎ
Ž2í¶èî¡�ÝNjñ…®Ál#èÈ=ÄFó ž×PÑØ GtÓ†3.píˆà5 7>¾³.vƒ¾¸/ÓÎú#Á×Ã.«�Ð~ëÈfõŸ3ØÃ8ÍN×’ÀÌ8#w:vÛN~TF?pŠÀPUÔQM8o…8ø¶ê1FôàM÷nÿ�¯‡�EÐN(`Ý‡­õ+ÞÎTñN8ÎFŽÔv�S¦<ã¬4NH±�Ê„üØúÈ þSY`„;EcÅ€‚Pu/Vq…n¹×¤ïŽ58H;”=Wà`€ÝSŸ×¸Ž E¸á1‹Ãc�†J� ô÷í¡S±CØ.}~Ï>óë”Çã…`„ÔA8­ð#öø,NrWu+L‹Ã1÷çNáJÛ�÷ÃS�Èþßì‡ßáýÃ#HëO9ÿvÓqë­KÏcñCœ½Íöë­AÇyÔ3Ä!JÄwø!|Û…lzÔp×o€7S�'^µÓÝræmƒÇSEµ^µÏuÛpÓ#NÏyôÑwÿl1ÃüŽ8üu÷Ÿ„ßÒóøMQÿ\E3vã�+!óÏ·»�Äâu;ä@ü©_ÎO±â>¹(ôöâŠ�ûÿ#ëè�B=ïÞ/«å•ahÛ6‹„�‹kšà € M@GY468Œ ;˜:áÓ€;�o÷3ø“ÚS0Àˆ §3L‡Îw£Ó?“?;êÎ®¿¯«³Ü¬ðêÿ-Nål ïê@¯’:œ7ìÕW¡¤`­É =³ødpª³ú‡(÷+©d�îŠõx]í›°¹®¨jeª<jÃæ‚•V†¥ÕZ—1ikˆ"-) T¿ÐïôÐÑI�ScnÖ’Ó_B T¿ÐïôÐÑI�ScnÖ’Ó_d¿?åï?oÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ãîšôRHAª��ê�U;ð¢fö«áµÐaÊ³a¡u74+¼<èkaà7]l8îóÈ¯-3@3ð®ª-GÇâð�áaxÐq3lƒƒÜp2¾ŒÓˆìr‹xS@x8æ€Å#À4¾-»~Žøñ&öØ8cXÃ6s¡¼9øý¬}õ1]³lLMÉìðº,m�Åm ìÏOŠÏCµÍ�ÇA»,‡öcã£Å›`�V:®¶Çˆ<8ƒÎmdÊ!š8Q:1`8|ëìŽ§	³Îük4Í³ë›>ºJë„À{€+‡ÇÔÇ?_�mÄjÆ½óÏ®aP :Álªððàa¾ôÌ»c�+¬ýÿ^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bâgË¹9 Ém‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=ørÇÀFïÆÿ˜  …  ´  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  2<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="13" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3277" maxFusedRunOn="3277"><Segment range="2537-2539" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2540-2542" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2543-3253" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Ehd2-m" directionality="1" translationMW="61175.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3277" maxFusedRunOn="3277"><Segment range="908-2536" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7562-7666" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5373-5494" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4189-4324" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3297-3521" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4009-4338" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3567-3995" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5945-6530" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4405-5199" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7492" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6701-7492" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7493-7561" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>4fe95725-b311-488d-82a7-5e84fea11bf2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:53:9">2025.5.29</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="3253..7729" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="3253..7729" colors="black"/></BottomStrand></StrandColors>  !’     ô  h        h7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÏ}ŠÓƒ…ðL~öó|‡í¿µâlÜW®¿àAwŸ*€º½­ðþ…áë5`Ž<=&MðÕ}:ÛÒ~¸AKø;ó /Äý÷ÇŽ²-�ƒÑ|�ÁXîÊ DSúóWµþ¨Þ«µÐ©ˆÏ×¿×Ð¾M´Ûlw>¾mÕtD„òqëôâøÎ
Ž2í¶èî¡�ÝNjñ…®Ál#èÈ=ÄFó ž×PÑØ GtÓ†3.píˆà5 7>¾³.vƒ¾¸/ÓÎú#Á×Ã.«�Ð~ëÈfõŸ3ØÃ8ÍN×’ÀÌ8#w:vÛN~TF?pŠÀPUÔQM8o…8ø¶ê1FôàM÷nÿ�¯‡�EÐN(`Ý‡­õ+ÞÎTñN8ÎFŽÔv�S¦<ã¬4NH±�Ê„üØúÈ þSY`„;EcÅ€‚Pu/Vq…n¹×¤ïŽ58H;”=Wà`€ÝSŸ×¸Ž E¸á1‹Ãc�†J� ô÷í¡S±CØ.}~Ï>óë”Çã…—±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚  …  	ê  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="Ehd2-m" directionality="1" translationMW="61175.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2539" maxFusedRunOn="2539"><Segment range="908-2536" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6848-6952" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4659-4780" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3475-3610" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2583-2807" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3295-3624" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2853-3281" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5231-5816" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3691-4485" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6778" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5987-6778" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6779-6847" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>4fe95725-b311-488d-82a7-5e84fea11bf2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:53:2">2025.5.29</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  q<StrandColors><TopStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="2536..2536" colors="green"/><ColorRange range="2537..7015" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="2536..2536" colors="green"/><ColorRange range="2537..7015" colors="black"/></BottomStrand></StrandColors>  Ê     ô  e        e7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÏ}ŠÓƒ…ðL~öó|‡í¿µâlÜW®¿àAwŸ*€º½­ðþ…áë5`Ž<=&MðÕ}:ÛÒ~¸AKø;ó /Äý÷ÇŽ²-�ƒÑ|�ÁXîÊ DSúóWµþ¨Þ«µÐ©ˆÏ×¿×Ð¾M´Ûlw>¾mÕtD„òqëôâøÎ
Ž2í¶èî¡�ÝNjñ…®Ál#èÈ=ÄFó ž×PÑØ GtÓ†3.píˆà5 7>¾³.vƒ¾¸/ÓÎú#Á×Ã.«�Ð~ëÈfõŸ3ØÃ8ÍN×’ÀÌ8#w:vÛN~TF?pŠÀPUÔQM8o…8ø¶ê1FôàM÷nÿ�¯‡�EÐN(`Ý‡­õ+ÞÎTñN8ÎFŽÔv�S¦<ã¬4NH±�Ê„üØúÈ þSY`„;EcÅ€‚Pu/Vq…n¹×¤ïŽ58H;”=Wà`€ÝSŸ×¸Ž E¸á1‹Ãc�†J� ô÷í¡S±CØ.}~Ï>óë”Çã…ìK‘ò¥8m>Çˆúä£ÓÛŠ*?ïü�¯¡þ÷¿x¾¯–U„£lÚ.B-®k€ €45 hdÐØà0€î`ë„0T_N î@	¿ÜÏâL3iLÃ ‚œÍ29Þ�LþLüï«:ºþ¾®Ïr³Ã«üµ;•°¿©¼jHêpß±ÿU^†�!‚·$€öÏá‘ÂªÏê KÜ®¥’º+Õà]wµþnÂæº¡©”¨ñ«š
UXN—Uj\Å¥® Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û�¸NkÑI!:ª>Cª5TïÀN‰›Ú¬†ÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬VSý~=·«÷Ï>¹…B€ë²«ÀsÃ�†ûÓ0íŽ®³÷ýz*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹‰Ÿ,~ääNƒ%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy]& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË¿þ`  …  	ç  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="Ehd2-m" directionality="1" translationMW="61175.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2560" maxFusedRunOn="2560"><Segment range="908-2536" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6845-6949" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4656-4777" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3472-3607" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2580-2804" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3292-3621" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2850-3278" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5228-5813" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3688-4482" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6775" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5984-6775" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6776-6844" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>4fe95725-b311-488d-82a7-5e84fea11bf2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:51:6">2025.5.29</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..7012" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..7012" colors="black"/></BottomStrand></StrandColors>  °     ò  _        _7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìØ­88Q@À? ôÇáo7È~ÛûPN&ÍÅzëþyò¨«ÚßèQŽ±ÃWöàƒÃÒdßWÓ­½'ë�4¿ƒ¿2üOß|xë âØØ17ÈüŽì¢ôE?¯5{_ê�]ê»]
˜Œý{ý}àDÛM¶ÇsàÛæÐ�WDHO ç¿N/Œà¨ás ~ÛnŽêýÔàF¯ZìöÂ>ŒƒÜA”o2	íu‚wM8c2ç ÎØ€ÎP‚sáë2çh;ë‚ý<ï¢<|2ê±8]î¼†oPùó=Œ3ŒÔíqù!\Ã‚0's§m´çáEDc÷¬]EÓ†øS�‹n£oNßvïøêøxôQ�â†ØzßR½ìåOã�äaØàýGhõ:cÎ:ÃAàD‹àHÐ0Œ¨@ßÍ€ÿ¬�0á…5‘A´Q†<X!õRõgVë�zNøáƒS„ƒ¹CÕ~Õ9ý{ˆà[�N±ñ68a¨úO~Úå;=‚ç÷×çüóà�>¹LqÑ@î8^Ä¹?*Wó†Óìx�®J==¸¢£þÿÈúúàP�{÷‹êùeXAZ6Í¢á$"Úæ¸  AÓP€QÖMŽ cæ¸CEôàä ›ýÌþ$Ã6”Ì0")ÌÓ!ó�èôÏäÏÎú³«¯ëêì÷+<:¿ËS¹[ ;ú�+Æ¤Ž§ûõUèi+rHlþ*¬þ¡Ê½ÊêY {¢½^×{_æì.kª™@j�°ù ¥U„á©uV¥ÌZZâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ¸û„æ½’Cª Cä:£UNüè™½ªÁ¸mDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~±Á°»ñ¿æ  …  	á  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  û<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="Ehd2-m" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2554" maxFusedRunOn="2554"><Segment range="902-2530" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6839-6943" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4650-4771" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3466-3601" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2574-2798" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3286-3615" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2844-3272" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5222-5807" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3682-4476" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6769" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5978-6769" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6770-6838" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>4fe95725-b311-488d-82a7-5e84fea11bf2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:50:57">2025.5.29</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..7006" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..7006" colors="black"/></BottomStrand></StrandColors>   €     Â  ¿         ¿7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÐÐàŸÁkð²Ç÷2ð»èH±Rßb´àáE üÓ„=¼ß!ûoíA8›7ë¯ø]çÊ .¯k|?¡F8zÇ_Ø#‚I“|5_N¶ôŸ®ÐRþüÈñ?}ñã¬ƒ‹c`Ät@ß#ðV;²ˆÑþ¼Õíªwªít*b3õïõô/�m6ÛÏƒo›B5]!<ƒœzý8¾3‚£…Ì�ûmº;¨c÷S�¼ak°CÛú2qQ¼È'µÔ4vÝ4áŒËœ;b8BÏ„/¬Ë� ï®ôó¾ˆðuðËªÄàAtºò½CçÌö0Î3SµÇä…p3À�Î�¶ÓŸ…�Ü"°uSNáN>-ºŒQ½8}Û¿àG«áãÑF4Š7aë}J÷³•<SŽ3‘‡cƒõ£Ôé�8ë�,C�#@Â2¡6þ²À?†ÖD!ÑFñ` ‡ÔKÕœa[®ué;ã†NåUø 7Tçõî#€n8LbÇÄpØàa„£è==ûhC”ìPöŸß_ŸóÏ‚<úå1ÇE¸áa4ÇŽÛïî£øâûý;Òƒ�Ã�ÌøîÞßããçøø9”„À®ïÝôv´…Mé‘Ð Hu>»‹Këwã~·gpN›tWgtvööÚÙ•Šª¾©ª¡Q.Ý—ä9þ…ë¦$á¡{­ºø;Þ¸ÈàJ46ßcà¨�/€&'ôÞ¾6yMîMxNv÷Oöôf¦„Þž&8à�|{´!Û�ÒÝÕÞôÔú¦JSNx§´ö9¿žê˜ºÐ�Þ+DÑÞÃ¯³¾í…þÄ¹?*Wó†Óìx�®J==¸¢£þÿÈúúàP�{÷‹êùeXAZ6Í¢á$"Úæ¸  AÓP€QÖMŽ cæ¸CEôàä ›ýÌþ$Ã6”Ì0")ÌÓ!ó�èôÏäÏÎú³«¯ëêì÷+<:¿ËS¹[ ;ú�+Æ¤Ž§ûõUèi+rHlþ*¬þ¡Ê½ÊêY {¢½^×{_æì.kª™@j�°ù ¥U„á©uV¥ÌZZâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ¸û„æ½’Cª Cä:£UNüè™½ªÁ¸mDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~±Á°»ñ¿æ  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  û<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="Ehd2-m" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3418" maxFusedRunOn="3418"><Segment range="902-3394" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7703-7807" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5514-5635" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4330-4465" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3438-3662" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4150-4479" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3708-4136" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6086-6671" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4546-5340" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7633" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6842-7633" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7634-7702" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>4fe95725-b311-488d-82a7-5e84fea11bf2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:50:29">2025.5.29</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..7870" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..7870" colors="black"/></BottomStrand></StrandColors>  æ      _  4         47»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �k�½7H0ó±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  Å<?xml version="1.0"?><Features recycledIDs="0" nextValidID="13"><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5260-5364" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3071-3192" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1887-2022" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="995-1219" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1707-2036" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1265-1693" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3643-4228" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2103-2897" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5190" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4399-5190" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5191-5259" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>4fe95725-b311-488d-82a7-5e84fea11bf2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:49:0">2025.5.29</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..5427" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..5427" colors="black"/></BottomStrand></StrandColors>  ¸ý7zXZ  æÖ´F !   t/å£àÇ*u] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉ;_xˆüW(ÛœõuÞ÷Mny6P%­Ì_AÇmg¡[û,—�$»7vùM—Âìø6„®�|2ÎÆPáûÏ—œ-¨‘ç­Bî ©Ÿ Q]�Šç�ýx½ož–ê¨‹OA:ÖóÀ¼Ì—lÕd¹Oªëƒu]×	$ñ”I} Ô2N@Aƒp éîãàM€RdèŠÜYl¥m�n~ë¹Æ4<�ŒÕðÈ¯=›Ý––çÝ 9®­èþ”HWÅ ,¡qEáÎ†7åÕf¿ŒrX^Þ.~ßnËƒ^ÓxÇ}:ÄÍD�±§)EJ!t²ó‡§¹o¬J±HŸžÖ¿°¥aeu®°–tn©sl	ô™ðOhtˆ¦Õñ~òªÝ¤	¦Ræsm¤î—îÚ{Â‰ã‚|{aþÑž¾-ðìÒ—[íUâÈŠ`‘“3\ü÷gŒ¾¤æ2æ]0S:3móAaŽ&;ý{ÄÒJJ”Mv	óÑ#· O2ˆ¹ïZ™àëkÂ„ /™:YùG÷[Y¤dlµ·Ôâ×F1ø?H�¸¾þ•¬Šå¥ôšºûUC)�6pj€ÈÐ`¦a/\Äþlv“i�âR]Mou²ïÄÈX/ (ÕZ°mâKõÓï§­—�ÙØÓ–ÁGãk,§M¡© jí„vÅ+%®<óÃÐ�ð¯ÕÏW½0ŸkXÈ{œ
@ó¯Ëõ-Gv¨Dõê)gk14-^µ’�×Êñ‰™]=òáyœôîÄ{á"·Â`€*!šsÝŠý¬¯ˆÍ¹‡H>¬ñþÓYÖI—Þ x\xÂ£é—AÀaÂNÉLâŒ#MM®0¡7h	š0­Ú­Ý¾ ñYZß² õÔäŠ…ð„ZV{v$Ëáý®Ž(®§tœÿ�™Ôgé&ÒVh­vf¯a�ÚÒÜt²<ä‰~î÷+¢¢ qâ¢f­rÕKÕ{;NŸ»BhÎQÿQêï´Lþ'É0Œ*æã(òþào¢cè[%‚¾ç½áqiªË=Ž]ß2tlÊpÞòmiáŸÏ±BßI3˜2¢ÚÆƒíÏ©›7ï•{“mUš²Ý´ ±UÏdYŒ§tr±ìÝÇãW8
lw Î¾nJÃƒpó£ ¤°8›“£/ú\<“ý:äˆÖÀ¶|ù³¦MJJw_BaÑjI½2x	`¹ûò[ºezGî3,aÄCj–Ì·Z­¥ |9Mõæ@,—…—É\¤pnQþ
4•{¯h/‚‹ž%åª¸ŽÝàËþäÂ!;ÁJ&¾â�õ„�[gJ&¡M"‡}<�¦ŠB×“´¦9¤!sJEãèeJ@†Üô¢ w™'±Àï'0ÇMÕßå¤T\�—2Œ
ßXtû*­|3O’¾µŽç‘÷&OÞJsÃ%€õÓOJwí~#8,Uã@´RÁjû)dùz,Ñu@”«÷=;�‡V˜frž>ïŽ¯Àh•>*æ¼5Ø_ÍËg<¤)B@åœ}Êk	M•)¨E›srZuÚD}ˆ�Ð-Yå¢’DÞweæ61>Z¹›TX¸*Ã>Þk·¬Žjëì½AIÑ£ÖîÞvÌ¤ÖÓNJ¡¹�Ï‰|ÏRÊ=?|ÇßÉ™ÍÈÛÎâlÅ�FŽ—ì1ØS’Jsg6²ú�“ÎNÂ‰Ó5L¸ƒ':ÈÖ³Æ7›NØ$�(Õzªu»‘LÎ=å�C1…ñUþØ62�QÐ(—¾m)=�5øb–‘&‡1§&<,nR„zS²]á;¶"cVÛÌ¸H‰à:)MjãQ¬MÈ˜¦¹1Çmu•K Òƒ våÿõ©&p|D	c?¾©º5©èŽí�Åò­bO<tPÈšJŸàK~>´Ê~ˆè|«Þè9(Z� ¢qÕŸÜ.×U+	ê’o…Ôàç¬øp]b‘D�Ï…2µdÕÒ{Xí¿UêH´:;¢½þP’ìMæ¼OF�Ó"�®ðÅÙ¼/ÌTz„ëqE}›â£x‘v#)½ªÿT¤@ö¥s-gÇ<Ôäõ-HŠ2§9ÇÛÌ\‡lÚˆ†-ñŠ>÷ëçŒÎÔ�oH7š³ù*Ño*¤Ð~m =ul“žwê¿ƒë¤Q8´Ý#èØz×·“|b¨™\ÿ½½¬&¢¾Ë0Lr‡e"nÚéõ$f•iÅO’�zJ‡ž´EDÖ%4€â€ƒ¹ûÓ	ênóqxç‹(4‡Xïk…XzéîH\½i�„“¨iM«Ê>wcØŽaµJaaŠûTyV’¦•Êo&]š·Ùª2Œ¸îWé¯÷òÔña�k'Ê9‘œXÔ™ØS;:o5¥0AËekä0¿îA»êh¬æö_Éz”0›¡°‘‰•aÑ¬n¢áp0ï"ÛM“’VÚÙúßºQÊSêò½W»®¹ÏEüg÷ÚCŠ%ÂÄ�í¼LdÒÜmLÑGöÌÐ8œ­µvêK"CÙÝŠõ¡*,+þš\íiì®€Pƒ†iåa=t·iN£G§=7öÞ#ÃÛ¢ÕNoÞU~q¡]«_–EÚò¨:t|ªñÙö‚sÿºÉB�Úgì–ÁÆ%,â¯ ôÛo›Þ“˜xgUjyÃØpG1\è:L1X1J*GöIt¡m”a[¦�9˜’>aå‹*>õ�²˜Fx’oy©� ý®HŸs\¶ï(…åb­�CZ=Uþék€Z ySV¿}î¤kÏÊãS´e«y‘¬1ß6^	š«,v÷,h¨ »ÒŒ‰‰(„>d‚ý<%`a©@XÔ&leSHì ýIÌlÐ�Õ¸½KÊŽúG®‡(¦ˆ«ƒLÑùY©lÃU�ÞM—2¹‡ú~�n.CQ¸-ÙCö#…[‰OIƒ1_†³`[(&k39ç'JvÇ·mqŠ©|ŠÄ&Äé3­›Ë –MÅÓ�¹¹Ýhè ƒäv!³~0É©ð1ÑSP=Ô)L\7�n»¢�Y[¥úÅƒY¨r]àvö‰Ûòß°å|‘Ý�¥øjÇf0@ˆßú�l
a!WÄñ¾Åxú-¹è\£sþyÃ“Ì› Í˜:¬Äül^á
^3ÕNô½{ÙNÓÃRpQ	õxc„kžÜhâ%—Ùy�s¥É6Â®Ø�Ò :]æ-Sb¹ž˜ôôôc�_¡Ô˜òÓU’ŒâÜsßZÎ÷‡ÜÎþgLV)M¥N/QeÍË`÷_tl{õn»‚Š®ýúñ2Ü1¥x5š´špš<þÈ¡ü¼e÷`Ÿ?‹ü_æÐ.Å¢Ý—Iº\öÈ�äà€þ«gƒ-m�²´7›/ü’˜oG/Ìoá®.%%wòº'ù¼^$±¯¢è³ì(…cvÑ
H
,‚w“œ¾™¨HõS*L^Æër¥Ý»wùMsÄÝK‡¡ÅÄ•e?‰ÔK<(;C[70béÇ·Ðd*†dªür÷þËåxnôBÀ™sÐ,µÜYÓ“È	�2S²ØT w‡ÒŠ3gWìQŸ‘ÛÜÑÄØ.ìÃŠZ8ýiua•	{…”‚æÍ™nFHÑ}Ñû±z�àXZdÃ?„VT;XðDÆ.ÃâŽÿøpeØw)e…AâÖYÀ.}¡o]5Í5�î¨nT ®äp7nag'”‹É{z–;_s× Œ>ŒBRV}ùb²mG ƒS¤±då¾–Y]óúþdßÊ.sÈîo‡FèX¿/=Ü”Û8j0Ø03z%HB'AÉqëÅð°ÀŽ(¤=n·e·�)&o˜[�(ôˆµ’™€ÝÉOü¸!ÂjvvEˆ,Ö ¡Å2|BöìvC³÷m%Ã¹¬ZD‡¨3YòëX¦OÖ+×®šçü$áq _1È@N·s°6�šé[Fð@³åI¹Ù—GRÓ€cî«Z)"õÑeäpFW�jMT³vaX}²UéÎ1ñíhÔ·˜)/¦¸‡yëH•í“‚Wâl¯Žž˜ü¤»À,C:IYKº5IIÏrãÓ(ó/¶±£÷Ö}CåX¶©í�ÿj(‡û›¥ýD²uÍëEØªô´-›æ�÷gmÈ¬è±Ô©¼ËJ!w,äŠ™ú>Ý_æzè–°Í+P1:Ñß|â®/;Ÿ{üð/)  ·L˜CslU²•\énd¾+$À´N1¤,©zãðÑ‚>Ž“g©\-Âbd'€k×—E2ýÖYá~Ö_IOÎ&^µÑ¦å4n;3Nz#o3—ü'­¸â‡tçô=Àú�x}~�sŽ`pæögê­¡hÂêøEÈÜ½PM½:/yÞœ’-TZ3Eô½Ðß<Š¸u¶™íTçì/i>ja�–˜Sr¯‚Š?™ßs‘ŒÀ•¸'ç-ÚÆt¿×1O`/U€Cjg¹†ohõoº‚å1ÎÚ¹}Hž#äOì¯>:ÔÜ¥…‡ ¬ëŸÖ|Üüž¨®ÙâÂêŠ§(     Wbìž’Û ‘«Ž åL³X±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  !Æ<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="0" name="mTagBFP2" directionality="1" translationMW="26654.94" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="3" hitsStopCodon="1"><Segment range="2573-3286" color="#3366ff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced monomeric blue fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/22174863&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/22174863&quot;&gt;Subach et al., 2011&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MVSKGEELIKENMHMKLYMEGTVDNHHFKCTSEGEGKPYEGTQTMRIKVVEGGPLPFAFDILATSFLYGSKTFINHTQGIPDFFKQSFPEGFTWERVTTYEDGGVLTATQDTSLQDGCLIYNVKIRGVNFTSNGPVMQKKTLGWEAFTETLYPADGGLEGRNDMALKLVGGSHLIANAKTTYRSKKPAKNLKMPGVYYVDYRLERIKEANNETYVEQHEVAVARYCDLPSKLGHKLN*"/></Q></Feature><Feature recentID="1" name="source" type="source" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="2573-3286" color="#ffffff" type="standard"/><Q name="mol_type"><V predef="other DNA"/></Q><Q name="organism"><V text="synthetic DNA construct"/></Q></Feature><Feature recentID="2" name="source" type="source" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="2573-3286" color="#ffffff" type="standard"/><Q name="mol_type"><V predef="other DNA"/></Q><Q name="organism"><V text="synthetic DNA construct"/></Q></Feature><Feature recentID="3" name="2Ã—linker" directionality="1" translationMW="648.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3286" maxFusedRunOn="3286"><Segment range="2537-2566" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGSGGGGS"/></Q></Feature><Feature recentID="4" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7525" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6734-7525" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7526-7594" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="5" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4438-5232" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5978-6563" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3600-4028" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4042-4371" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3330-3554" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4222-4357" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5406-5527" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7595-7699" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="Ehd2-m" directionality="1" translationMW="61175.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3286" maxFusedRunOn="3286"><Segment range="908-2536" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MFSWLKKGGARGQRPEAIRTVTSSLKELYRTKLLPLEEHYRFGSFHSPALEDADFDGKPMVLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGETEGTVPGNALVVDPEKPFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAERVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWALGKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKRARLVRVHAYIISYLKKEMPTVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDDMLAQDIAKLMPLLRQEELESVEAGVQGGAFEGTRMGPFVERGPDEAIEDGEEGSEDDAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPTNLPRRLVPPSKRRQKGSAE"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¨<Notes>
<UUID>252b2361-38e0-4e15-9ec6-b2aec859bc7b</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-Ehd2(mouse)-mTagBFP2-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="1:39:14">2026.1.30</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             s<StrandColors><TopStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="2536..3285" colors="purple"/><ColorRange range="3286..7762" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..900" colors="black"/><ColorRange range="901..902" colors="blue"/><ColorRange range="903..906" colors="green"/><ColorRange range="907..2535" colors="black"/><ColorRange range="2536..3285" colors="purple"/><ColorRange range="3286..7762" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
